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Provedor de dados:  Nature Precedings
País:  United Kingdom
Título:  2011 German Escherichia coli outbreak: Alignment-free whole-genome phylogeny by feature frequency profiles
Autores:  Man Kit Cheung
Lei LI
Wenyan Nong
Hoi Shan Kwan
Data:  2011-07-12
Ano:  2011
Palavras-chave:  Genetics & Genomics
Microbiology
Bioinformatics
Evolutionary Biology
Resumo:  Accuracy of SNP-based whole-genome phylogeny reconstruction relies heavily on quality of sequence alignment which is particularly hindered by poorly assembled genomes. Alignment-free methods might provide additional insights. Here, we constructed a whole-genome phylogeny of 9 E.coli isolates from the 2011 German outbreak against existing E. coli genomes using the alignment-free feature frequency profile method. In addition, we looked for gene elements that distinguish the outbreak group from the other E. coli strains and possibly accounted for the emergence of the outbreak isolates using the distinguishing feature analysis.
Tipo:  Manuscript
Identificador:  http://precedings.nature.com/documents/6109/version/1

oai:nature.com:10.1038/npre.2011.6109.1

http://dx.doi.org/10.1038/npre.2011.6109.1
Fonte:  Nature Precedings
Direitos:  Creative Commons Attribution 3.0 License
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